Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, … Wu J-W, Lin L-C, Tsai T-H. Drug–drug interactions of silymarin on the perspective of pharmacokinetics. A … However, little conclusive information is available about milk thistle interactions. James F. Balch and Mark Stengler, authors of “Prescription for Natural Cures,” say that milk thistle is beneficial … Milk Thistle Drug Interactions. Milk thistle is one of the more popular herbs, as it is well known for its role in liver health. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Milk thistle can also produce estrogenic effects, so those who suffer from endometriosis or uterine fibroids should avoid milk thistle because of the possible contraindication. Laboratory studies suggest that milk thistle or some of its … Early research suggests that milk thistle … Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. USES: Milk thistle has been used for diabetes in combination with … Closely monitor your blood sugar levels. The study is created by eHealthMe based … Content is best viewed in IE9 or above, Firefox and Google Chrome browser. Talk to your doctor: Milk thistle does interact with warfarin & therefore should not be taken until you discuss with your primary medical provider or specialist. The seeds of the milk thistle plant are commonly used to protect the liver from damage caused by hepatitis viruses as well as alcohol and other substances. Common side effects may include: indigestion, bloating, gas, stomach pain; diarrhea; or nausea, loss of appetite. I read about an enzyme, CYP3A4, that is affected by milk thistle and Effexor is a substrate (not sure what that means) when broken down by the liver. Therefore, before using this product, tell your doctor or pharmacist of all the products you … They may decide to adjust your warfarin dose … Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Reviewed By: Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. 3. Rate your experience with MILK THISTLE on WebMD including its effectiveness, uses, side effects, interactions, safety and satisfaction. A Warning About Milk Thistle and Drug Interactions. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Diabetes medications. Milk Thistle Drug Interactions. Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural product–drug interaction. /publications/issue/2015/September2015/Milk-Thistle-Drug-Interactions, Copyright Specialty Pharmacy Times 2006-2019, 2 Clarke Drive Suite 100 Cranbury, NJ 08512 P:609-716-7777 F:609-716-9038. Taking milk thistle might affect this enzyme and drugs it processes, such as diazepam (Valium), warfarin (Coumadin, Jantoven) and others. Early research suggests that milk thistle … Milk thistle might lower blood sugar in people who have type 2 diabetes. Milk thistle may interact with other drugs. If milk thistle is taken by someone using protease inhibitors or non-nukes, it has the potential to raise levels of these drugs, causing unpleasant or even dangerous side effects. How the interaction occurs: Milk thistle may slow down how quickly your body processes warfarin. Metronidazole (Flagyl). Milk thistle might help the body break down estrogen pills to get rid of them. See what others have said about Milk Thistle, including the effectiveness, ease of use and side effects. Milk Thistle; Silybum marianum; St. Mary's Thistle. Other less common side effects are nausea, diarrhea, indigestion, … No interactions found. This document does not contain all possible interactions. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. One reported effect of milk thistle is that it can boost breast … Diabetes Home > Milk Thistle Drug Interactions Although it is a dietary supplement , milk thistle can theoretically interact with medications. 30 July 2001. The study is created by eHealthMe based on … Taking milk thistle with diabetes drugs might cause additive effects. Skip to content Check Your Symptoms Find A Doctor Find Lowest … Common interactions include fall among females and fatigue among males. The American Journal of Pharmacy Benefits. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. John R. Horn, PharmD, FCCP, and Philip D. Hansten, PharmD. Milk thistle is a herbal product widely used in the United States and around the world. Although it is a dietary supplement, milk thistle can theoretically interact with medications. Milk thistle may interact with some medications, including allergy medicines, anti-anxiety drugs and blood thinners, among others. Below is a short list of some … Milk thistle extract is LIKELY SAFE when taken by mouth for most adults. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. Deng JW, Shon JH, Shin HJ, et al. Drug interactions are reported among people who take Milk thistle and Metformin. Milk thistle does not appear to affect the pharmacokinetics of irinotecan. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. Milk thistle + Irinotecan. It may lead to … Some cellular studies found that milk thistle may affect CYP enzymes in the liver that metabolize drugs; … However, little conclusive information is available about milk thistle interactions. It Can Boost Breast Milk Production. Milk thistle and compounds derived from it are commonly used as herbal supplements for liver problems, but study results are mixed. Similarly, the fact that milk thistle … The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Milk thistle may excessively lower blood sugar in people on antidiabetic drugs. Common interactions include insomnia among females and fatigue among males. Milk Thistle received an overall rating of 0 out of 10 stars from 0 reviews. Evidence, mechanism, importance and management. Cytochrome P450 2C9 (CYP2C9) substrates. Related: PK and drug interactions. Reduce the typical dose if you’re worried about a potential interaction with your statin drug. A.D.A.M. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs-- such as fexofenadine … Drug interactions are reported among people who take Xarelto and Milk thistle. 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